PittsburghV1, France, Analysis, bibRecord, 000021

Impulse control disorders and levodopa-induced dyskinesias in Parkinson's disease: an update.

Identifieur interne : 000021 ( France/Analysis ); précédent : 000020; suivant : 000022

Impulse control disorders and levodopa-induced dyskinesias in Parkinson's disease: an update.

Auteurs : Valerie Voon [Royaume-Uni] ; T Celeste Napier [France] ; Michael J. Frank [États-Unis] ; Veronique Sgambato-Faure [France] ; Anthony A. Grace [États-Unis] ; Maria Rodriguez-Oroz [Espagne] ; Jose Obeso [Espagne] ; Erwan Bezard [France] ; Pierre-Olivier Fernagut [France]

Source :

Lancet Neurology [ 1474-4422 ] ; 2017-02-15.

RBID : Hal:hal-01490856

Abstract

Dopaminergic medications used in the treatment of patients with Parkinson's disease are associated with motor and non-motor behavioural side-effects, such as dyskinesias and impulse control disorders also known as behavioural addictions. Levodopa-induced dyskinesias occur in up to 80% of patients with Parkinson's after a few years of chronic treatment. Impulse control disorders, including gambling disorder, binge eating disorder, compulsive sexual behaviour, and compulsive shopping occur in about 17% of patients with Parkinson's disease on dopamine agonists. These behaviours reflect the interactions of the dopaminergic medications with the individual's susceptibility, and the underlying neurobiology of Parkinson's disease. Parkinsonian rodent models show enhanced reinforcing effects of chronic dopaminergic medication, and a potential role for individual susceptibility. In patients with Parkinson's disease and impulse control disorders, impairments are observed across subtypes of decisional impulsivity, possibly reflecting uncertainty and the relative balance of rewards and losses. Impairments appear to be more specific to decisional than motor impulsivity, which might reflect differences in ventral and dorsal striatal engagement. Emerging evidence suggests impulse control disorder subtypes have dissociable correlates, which indicate that individual susceptibility predisposes towards the expression of different behavioural subtypes and neurobiological substrates. Therapeutic interventions to treat patients with Parkinson's disease and impulse control disorders have shown efficacy in randomised controlled trials. Large-scale studies are warranted to identify individual risk factors and novel therapeutic targets for these diseases. Mechanisms underlying impulse control disorders and dyskinesias could provide crucial insights into other behavioural symptoms in Parkinson's disease and addictions in the general population.

Url:

https://hal.archives-ouvertes.fr/hal-01490856

DOI: 10.1016/S1474-4422(17)30004-2.

Affiliations:

Links toward previous steps (curation, corpus...)

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Hal:hal-01490856

Le document en format XML

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        <tutelles><tutelle active="#struct-343526" type="direct"><org type="institution" xml:id="struct-343526" status="INCOMING">          <orgName>Center for Applied Medical Research</orgName>
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</hal:affiliation>
<country>Espagne</country>
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</author>
<author><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-244085" status="VALID"><orgName>Institut des Maladies Neurodégénératives [Bordeaux]</orgName>
<orgName type="acronym">IMN</orgName>
<desc><address><addrLine>Bât. 3b 1er étage 146 Rue Léo Saignat 33076 Bordeaux </addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://imn-bordeaux.org/</ref>
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<tutelles><tutelle active="#struct-259761" type="direct"><org type="institution" xml:id="struct-259761" status="VALID"><orgName>Université de Bordeaux</orgName>
<orgName type="acronym">UB</orgName>
<desc><address><addrLine>35, place Pey Berland - 33076 Bordeaux</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.u-bordeaux.fr/</ref>
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<tutelle name="UMR5293" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
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          <orgName>Centre National de la Recherche Scientifique</orgName>
          <orgName type="acronym">CNRS</orgName>
          <date type="start">1939-10-19</date>
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<country>France</country>
<placeName><settlement type="city">Bordeaux</settlement>
<region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
</placeName>
<orgName type="university">Université de Bordeaux</orgName>
</affiliation>
</author>
<author><name sortKey="Fernagut, Pierre Olivier" sort="Fernagut, Pierre Olivier" uniqKey="Fernagut P" first="Pierre-Olivier" last="Fernagut">Pierre-Olivier Fernagut</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-244085" status="VALID"><orgName>Institut des Maladies Neurodégénératives [Bordeaux]</orgName>
<orgName type="acronym">IMN</orgName>
<desc><address><addrLine>Bât. 3b 1er étage 146 Rue Léo Saignat 33076 Bordeaux </addrLine>
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</address>
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</desc>
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<tutelle name="UMR5293" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">          <idno type="IdRef">02636817X</idno>
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          <date type="start">1939-10-19</date>
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            </address>
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</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Bordeaux</settlement>
<region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
</placeName>
<orgName type="university">Université de Bordeaux</orgName>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1016/S1474-4422(17)30004-2.</idno>
<series><title level="j">Lancet Neurology</title>
<idno type="ISSN">1474-4422</idno>
<imprint><date type="datePub">2017-02-15</date>
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<front><div type="abstract" xml:lang="en">Dopaminergic medications used in the treatment of patients with Parkinson's disease are associated with motor and non-motor behavioural side-effects, such as dyskinesias and impulse control disorders also known as behavioural addictions. Levodopa-induced dyskinesias occur in up to 80% of patients with Parkinson's after a few years of chronic treatment. Impulse control disorders, including gambling disorder, binge eating disorder, compulsive sexual behaviour, and compulsive shopping occur in about 17% of patients with Parkinson's disease on dopamine agonists. These behaviours reflect the interactions of the dopaminergic medications with the individual's susceptibility, and the underlying neurobiology of Parkinson's disease. Parkinsonian rodent models show enhanced reinforcing effects of chronic dopaminergic medication, and a potential role for individual susceptibility. In patients with Parkinson's disease and impulse control disorders, impairments are observed across subtypes of decisional impulsivity, possibly reflecting uncertainty and the relative balance of rewards and losses. Impairments appear to be more specific to decisional than motor impulsivity, which might reflect differences in ventral and dorsal striatal engagement. Emerging evidence suggests impulse control disorder subtypes have dissociable correlates, which indicate that individual susceptibility predisposes towards the expression of different behavioural subtypes and neurobiological substrates. Therapeutic interventions to treat patients with Parkinson's disease and impulse control disorders have shown efficacy in randomised controlled trials. Large-scale studies are warranted to identify individual risk factors and novel therapeutic targets for these diseases. Mechanisms underlying impulse control disorders and dyskinesias could provide crucial insights into other behavioural symptoms in Parkinson's disease and addictions in the general population.</div>
</front>
</TEI>
<affiliations><list><country><li>Espagne</li>
<li>France</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Aquitaine</li>
<li>Auvergne-Rhône-Alpes</li>
<li>Nouvelle-Aquitaine</li>
<li>Pennsylvanie</li>
<li>Rhône-Alpes</li>
</region>
<settlement><li>Bordeaux</li>
<li>Lyon</li>
<li>Pittsburgh</li>
</settlement>
<orgName><li>Université Claude Bernard Lyon 1</li>
<li>Université de Bordeaux</li>
<li>Université de Lyon</li>
<li>Université de Pittsburgh</li>
</orgName>
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<tree><country name="Royaume-Uni"><noRegion><name sortKey="Voon, Valerie" sort="Voon, Valerie" uniqKey="Voon V" first="Valerie" last="Voon">Valerie Voon</name>
</noRegion>
</country>
<country name="France"><noRegion><name sortKey="Napier, T Celeste" sort="Napier, T Celeste" uniqKey="Napier T" first="T Celeste" last="Napier">T Celeste Napier</name>
</noRegion>
<name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name>
<name sortKey="Fernagut, Pierre Olivier" sort="Fernagut, Pierre Olivier" uniqKey="Fernagut P" first="Pierre-Olivier" last="Fernagut">Pierre-Olivier Fernagut</name>
<name sortKey="Sgambato Faure, Veronique" sort="Sgambato Faure, Veronique" uniqKey="Sgambato Faure V" first="Veronique" last="Sgambato-Faure">Veronique Sgambato-Faure</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Frank, Michael J" sort="Frank, Michael J" uniqKey="Frank M" first="Michael J" last="Frank">Michael J. Frank</name>
</noRegion>
<name sortKey="Grace, Anthony A" sort="Grace, Anthony A" uniqKey="Grace A" first="Anthony A" last="Grace">Anthony A. Grace</name>
</country>
<country name="Espagne"><noRegion><name sortKey="Rodriguez Oroz, Maria" sort="Rodriguez Oroz, Maria" uniqKey="Rodriguez Oroz M" first="Maria" last="Rodriguez-Oroz">Maria Rodriguez-Oroz</name>
</noRegion>
<name sortKey="Obeso, Jose" sort="Obeso, Jose" uniqKey="Obeso J" first="Jose" last="Obeso">Jose Obeso</name>
</country>
</tree>
</affiliations>
</record>

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Impulse control disorders and levodopa-induced dyskinesias in Parkinson's disease: an update.

Impulse control disorders and levodopa-induced dyskinesias in Parkinson's disease: an update.

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